Assay Detail
Binding
CHEMBL1058321
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Inhibition of PDE11
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.77 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560408 | — | — | 1 | 8.23 |
| CHEMBL561952 | — | — | 1 | 8.11 |
| CHEMBL560687 | — | — | 1 | 8.09 |
| CHEMBL558338 | — | — | 1 | 8.09 |
| CHEMBL563130 | — | — | 1 | 7.44 |
| CHEMBL557266 | — | — | 1 | 7.39 |
| CHEMBL560609 | — | — | 1 | 7.10 |
| CHEMBL563637 | — | — | 1 | 7.04 |
| CHEMBL557755 | — | — | 1 | 6.84 |
| CHEMBL550007 | — | — | 1 | 6.67 |
| CHEMBL550817 | — | — | 1 | 6.54 |
| CHEMBL557467 | — | — | 1 | 6.49 |
| CHEMBL556514 | — | — | 1 | 6.46 |
| CHEMBL557059 | — | — | 1 | 6.41 |
| CHEMBL559889 | — | — | 1 | 6.39 |
| CHEMBL560545 | — | — | 1 | 6.32 |
| CHEMBL556863 | — | — | 1 | 6.32 |
| CHEMBL563661 | — | — | 1 | 6.25 |
| CHEMBL562208 | — | — | 1 | 6.01 |
| CHEMBL563669 | — | — | 1 | 5.92 |
| CHEMBL558729 | — | — | 1 | 5.91 |
| CHEMBL564374 | — | — | 1 | 5.81 |
| CHEMBL550131 | — | — | 1 | 5.78 |
| CHEMBL558466 | — | — | 1 | - |
| CHEMBL561548 | — | — | 1 | - |
| CHEMBL552025 | — | — | 1 | - |
| CHEMBL561088 | — | — | 1 | - |
| CHEMBL562756 | — | — | 1 | - |
| CHEMBL550478 | — | — | 1 | - |
| CHEMBL565116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560408 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL561952 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL560687 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL558338 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL563130 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL557266 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL560609 | — | IC50 | = | 79.2 | nM | 7.10 |
| CHEMBL563637 | — | IC50 | = | 90.9 | nM | 7.04 |
| CHEMBL557755 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL550007 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL550817 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL557467 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL556514 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL557059 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL559889 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL556863 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL560545 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL563661 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL562208 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL563669 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL558729 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL564374 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL550131 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL558466 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL561548 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL552025 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL561088 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL562756 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL550478 | — | IC50 | - | — | - | |
| CHEMBL565116 | — | IC50 | - | — | - | |
| CHEMBL565024 | — | IC50 | - | — | - | |
| CHEMBL551948 | — | IC50 | > | 2000.0 | nM | - |