Assay Detail
Functional
CHEMBL1058711
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552054 | — | — | 1 | 8.10 |
| CHEMBL502127 | CALACTIN | — | 1 | 7.70 |
| CHEMBL447312 | — | — | 1 | 7.40 |
| CHEMBL469426 | — | — | 1 | 7.30 |
| CHEMBL559102 | — | — | 1 | 7.10 |
| CHEMBL499134 | GHALAKINOSIDE | — | 1 | 7.10 |
| CHEMBL555674 | — | — | 1 | 6.70 |
| CHEMBL556108 | — | — | 1 | 6.40 |
| CHEMBL558544 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552054 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL502127 | CALACTIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL447312 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL469426 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL559102 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL499134 | GHALAKINOSIDE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL555674 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL556108 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL558544 | — | IC50 | = | 800.0 | nM | 6.10 |