Assay Detail
Binding
CHEMBL1058716
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Inhibition of pig cerebral cortex Na+/K+-ATPase by colorimetric microplate-based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.22 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499134 | GHALAKINOSIDE | — | 1 | 6.52 |
| CHEMBL447312 | — | — | 1 | 6.40 |
| CHEMBL502127 | CALACTIN | — | 1 | 6.40 |
| CHEMBL559102 | — | — | 1 | 6.30 |
| CHEMBL555674 | — | — | 1 | 6.30 |
| CHEMBL469426 | — | — | 1 | 6.16 |
| CHEMBL558544 | — | — | 1 | 5.92 |
| CHEMBL556108 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499134 | GHALAKINOSIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL447312 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL502127 | CALACTIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL559102 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL555674 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL469426 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL558544 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL556108 | — | IC50 | = | 1700.0 | nM | 5.77 |