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Assay Detail

CHEMBL1058849

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Functional
Antiviral activity against HCV Con1 GT1b by replicon assay
ChEMBL ↗
55
Total Activities
52
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
McGuigan C, Kelleher MR, Perrone P, Mulready S, Luoni G, Daverio F, Rajyaguru S, Le Pogam S, Najera I, Martin JA, Klumpp K, Smith DB.
Bioorg Med Chem Lett (2009) 19 : 4250 -4254
PubMed 19505826 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 47 5.48 6.42
IC50 8 4.79 5.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL552121 — — 1 6.42
CHEMBL562941 — — 1 6.29
CHEMBL562127 — — 1 6.21
CHEMBL561067 — — 1 6.14
CHEMBL560665 — — 1 6.03
CHEMBL539443 — — 2 6.02
CHEMBL564433 — — 1 6.00
CHEMBL393857 4'-AZIDOCYTIDINE -1.0 1 5.89
CHEMBL540429 — — 1 5.89
CHEMBL540179 — — 1 5.68
CHEMBL541012 — — 1 5.66
CHEMBL559346 — — 1 5.64
CHEMBL541760 — — 1 5.64
CHEMBL564304 — — 1 5.64
CHEMBL555911 — — 1 5.60
CHEMBL555690 — — 1 5.54
CHEMBL550861 — — 1 5.54
CHEMBL541187 — — 2 5.54
CHEMBL541256 — — 1 5.54
CHEMBL555353 — — 1 5.51
CHEMBL558643 — — 1 5.51
CHEMBL558560 — — 1 5.46
CHEMBL553927 — — 1 5.43
CHEMBL554155 — — 1 5.39
CHEMBL557562 — — 1 5.38
CHEMBL553160 — — 1 5.37
CHEMBL559084 — — 1 5.36
CHEMBL562993 — — 2 5.35
CHEMBL563431 — — 1 5.25
CHEMBL558901 — — 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL552121 — EC50 = 380.0 nM 6.42
CHEMBL562941 — EC50 = 510.0 nM 6.29
CHEMBL562127 — EC50 = 620.0 nM 6.21
CHEMBL561067 — EC50 = 720.0 nM 6.14
CHEMBL560665 — EC50 = 940.0 nM 6.03
CHEMBL539443 — EC50 = 950.0 nM 6.02
CHEMBL564433 — EC50 = 990.0 nM 6.00
CHEMBL539443 — EC50 = 1200.0 nM 5.92
CHEMBL540429 — EC50 = 1300.0 nM 5.89
CHEMBL393857 4'-AZIDOCYTIDINE EC50 = 1280.0 nM 5.89
CHEMBL540179 — EC50 = 2100.0 nM 5.68
CHEMBL541012 — EC50 = 2200.0 nM 5.66
CHEMBL541760 — EC50 = 2300.0 nM 5.64
CHEMBL564304 — EC50 = 2300.0 nM 5.64
CHEMBL559346 — EC50 = 2300.0 nM 5.64
CHEMBL555911 — EC50 = 2500.0 nM 5.60
CHEMBL550861 — EC50 = 2900.0 nM 5.54
CHEMBL541187 — EC50 = 2900.0 nM 5.54
CHEMBL541256 — EC50 = 2900.0 nM 5.54
CHEMBL555690 — EC50 = 2900.0 nM 5.54
CHEMBL555353 — EC50 = 3100.0 nM 5.51
CHEMBL558643 — EC50 = 3100.0 nM 5.51
CHEMBL558560 — EC50 = 3500.0 nM 5.46
CHEMBL553927 — EC50 = 3700.0 nM 5.43
CHEMBL554155 — EC50 = 4100.0 nM 5.39
CHEMBL557562 — IC50 = 4200.0 nM 5.38
CHEMBL553160 — EC50 = 4300.0 nM 5.37
CHEMBL541187 — EC50 = 4300.0 nM 5.37
CHEMBL559084 — IC50 = 4400.0 nM 5.36
CHEMBL562993 — EC50 = 4500.0 nM 5.35
CHEMBL563431 — EC50 = 5600.0 nM 5.25
CHEMBL558901 — EC50 = 6000.0 nM 5.22
CHEMBL554797 — EC50 = 6200.0 nM 5.21
CHEMBL563102 — EC50 = 6500.0 nM 5.19
CHEMBL538128 — IC50 = 6700.0 nM 5.17
CHEMBL554822 — IC50 = 7700.0 nM 5.11
CHEMBL555691 — EC50 = 8800.0 nM 5.06
CHEMBL539694 — EC50 = 9200.0 nM 5.04
CHEMBL554136 — EC50 = 9200.0 nM 5.04
CHEMBL563103 — EC50 = 9300.0 nM 5.03
CHEMBL557307 — EC50 = 11000.0 nM 4.96
CHEMBL559475 — EC50 = 11000.0 nM 4.96
CHEMBL552538 — EC50 = 11000.0 nM 4.96
CHEMBL562993 — EC50 = 15000.0 nM 4.82
CHEMBL563537 — EC50 = 18000.0 nM 4.75
CHEMBL563101 — EC50 = 30000.0 nM 4.52
CHEMBL553198 — IC50 = 44000.0 nM 4.36
CHEMBL562386 — IC50 = 47000.0 nM 4.33
CHEMBL550797 — IC50 = 48000.0 nM 4.32
CHEMBL560524 — IC50 = 56000.0 nM 4.25