Assay Detail
Binding
CHEMBL1058857
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Inhibition of DPP4 by continuous fluorimetric assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.56 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564249 | — | — | 1 | 9.42 |
| CHEMBL563272 | — | — | 1 | 8.10 |
| CHEMBL561322 | — | — | 1 | 8.10 |
| CHEMBL563648 | — | — | 1 | 8.05 |
| CHEMBL561120 | — | — | 1 | 7.92 |
| CHEMBL564043 | — | — | 1 | 7.85 |
| CHEMBL549432 | — | — | 1 | 7.70 |
| CHEMBL560183 | — | — | 1 | 7.62 |
| CHEMBL565056 | — | — | 1 | 7.57 |
| CHEMBL562525 | — | — | 1 | 7.57 |
| CHEMBL563108 | — | — | 1 | 7.57 |
| CHEMBL560184 | — | — | 1 | 7.52 |
| CHEMBL539187 | — | — | 1 | 7.47 |
| CHEMBL560123 | — | — | 1 | 7.33 |
| CHEMBL550862 | — | — | 1 | 7.31 |
| CHEMBL549842 | — | — | 1 | 7.28 |
| CHEMBL562981 | — | — | 1 | 7.18 |
| CHEMBL557851 | — | — | 1 | 7.11 |
| CHEMBL563911 | — | — | 1 | 7.06 |
| CHEMBL425584 | — | — | 1 | 7.05 |
| CHEMBL553936 | — | — | 1 | 7.04 |
| CHEMBL552263 | — | — | 1 | 7.04 |
| CHEMBL562603 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564249 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL563272 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL561322 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL563648 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL561120 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL564043 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL549432 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL560183 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL565056 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL562525 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL563108 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL560184 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL539187 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL560123 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL550862 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL549842 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL562981 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL557851 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL563911 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL425584 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL553936 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL552263 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL562603 | — | IC50 | = | 94.0 | nM | 7.03 |