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Assay Detail

CHEMBL1058899

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Functional
Cytotoxicity against human A549 cells by sulforhodamine B assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship studies of cytotoxic anhydrovinblastine amide derivatives.
Shao Y, Zhang HK, Ding H, Quan HT, Lou LG, Hu LH.
J Nat Prod (2009) 72 : 1170 -1177
PubMed 19499938 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.48 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL538135 1 8.10
CHEMBL538943 VINORELBINE TARTRATE 4.0 1 8.05
CHEMBL554129 1 8.00
CHEMBL557394 1 7.70
CHEMBL538444 1 7.66
CHEMBL538944 1 7.62
CHEMBL554761 1 7.60
CHEMBL551080 1 7.58
CHEMBL557752 1 7.58
CHEMBL553868 1 7.57
CHEMBL562779 1 7.57
CHEMBL557753 1 7.52
CHEMBL553025 VINORELBINE 4.0 1 7.52
CHEMBL553869 1 7.48
CHEMBL541959 1 7.47
CHEMBL538874 1 7.41
CHEMBL541958 1 7.37
CHEMBL563785 1 7.02
CHEMBL556323 1 7.02
CHEMBL553111 1 7.00
CHEMBL541933 1 6.94
CHEMBL555758 1 6.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL538135 IC50 = 8.0 nM 8.10
CHEMBL538943 VINORELBINE TARTRATE IC50 = 9.0 nM 8.05
CHEMBL554129 IC50 = 10.0 nM 8.00
CHEMBL557394 IC50 = 20.0 nM 7.70
CHEMBL538444 IC50 = 22.0 nM 7.66
CHEMBL538944 IC50 = 24.0 nM 7.62
CHEMBL554761 IC50 = 25.0 nM 7.60
CHEMBL551080 IC50 = 26.0 nM 7.58
CHEMBL557752 IC50 = 26.0 nM 7.58
CHEMBL553868 IC50 = 27.0 nM 7.57
CHEMBL562779 IC50 = 27.0 nM 7.57
CHEMBL557753 IC50 = 30.0 nM 7.52
CHEMBL553025 VINORELBINE IC50 = 30.0 nM 7.52
CHEMBL553869 IC50 = 33.0 nM 7.48
CHEMBL541959 IC50 = 34.0 nM 7.47
CHEMBL538874 IC50 = 39.0 nM 7.41
CHEMBL541958 IC50 = 43.0 nM 7.37
CHEMBL563785 IC50 = 96.0 nM 7.02
CHEMBL556323 IC50 = 95.0 nM 7.02
CHEMBL553111 IC50 = 101.0 nM 7.00
CHEMBL541933 IC50 = 115.0 nM 6.94
CHEMBL555758 IC50 = 152.0 nM 6.82