Assay Detail
Binding
CHEMBL1058997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 recombinant reverse transcriptase p66/p51 heterodimer in presence of Mg2+
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.24 | 4.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562080 | — | — | 1 | 4.32 |
| CHEMBL572124 | — | — | 1 | 4.16 |
| CHEMBL557770 | — | — | 1 | - |
| CHEMBL16755 | — | — | 1 | - |
| CHEMBL550937 | BETA-THUJAPLICINOL | — | 1 | - |
| CHEMBL183852 | — | — | 1 | - |
| CHEMBL559337 | 7-DESHYDROXYPYROGALLIN-4-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL440562 | — | — | 1 | - |
| CHEMBL204900 | — | — | 1 | - |
| CHEMBL561881 | — | — | 1 | - |
| CHEMBL551212 | — | — | 1 | - |
| CHEMBL539211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562080 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL572124 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL557770 | — | IC50 | - | — | - | |
| CHEMBL16755 | — | IC50 | - | — | - | |
| CHEMBL550937 | BETA-THUJAPLICINOL | IC50 | - | — | - | |
| CHEMBL183852 | — | IC50 | - | — | - | |
| CHEMBL559337 | 7-DESHYDROXYPYROGALLIN-4-CARBOXYLIC ACID | IC50 | - | — | - | |
| CHEMBL440562 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL204900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL561881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL551212 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL539211 | — | IC50 | - | — | - |