Assay Detail
Functional
CHEMBL1059040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of clonogenic survival of human MCF7 cells after 10 days by microscopy
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.02 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444463 | — | — | 1 | 5.38 |
| CHEMBL560401 | — | — | 1 | 5.33 |
| CHEMBL558137 | — | — | 1 | 5.30 |
| CHEMBL568911 | — | — | 1 | 5.17 |
| CHEMBL563596 | — | — | 1 | 5.14 |
| CHEMBL558526 | — | — | 1 | 4.95 |
| CHEMBL2308038 | — | — | 1 | 4.50 |
| CHEMBL551679 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444463 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL560401 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL558137 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL568911 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL563596 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL558526 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL2308038 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL551679 | — | IC50 | = | 44700.0 | nM | 4.35 |