Assay Detail
Functional
CHEMBL1059042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of clonogenic survival of tumor necrosis factor-resistant human MCF7 cells after 10 days by microscopy
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.75 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560401 | — | — | 1 | 5.11 |
| CHEMBL444463 | — | — | 1 | 5.07 |
| CHEMBL568911 | — | — | 1 | 4.96 |
| CHEMBL558526 | — | — | 1 | 4.82 |
| CHEMBL558137 | — | — | 1 | 4.82 |
| CHEMBL563596 | — | — | 1 | 4.63 |
| CHEMBL2308038 | — | — | 1 | 4.30 |
| CHEMBL551679 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560401 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL444463 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL568911 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL558526 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL558137 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL563596 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL2308038 | — | IC50 | = | 49600.0 | nM | 4.30 |
| CHEMBL551679 | — | IC50 | = | 52700.0 | nM | 4.28 |