Assay Detail
Binding
CHEMBL1059153
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Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.22 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282199 | — | — | 1 | 8.92 |
| CHEMBL557330 | — | — | 1 | 8.22 |
| CHEMBL204171 | — | — | 1 | 8.10 |
| CHEMBL497749 | — | — | 1 | 7.70 |
| CHEMBL561346 | — | — | 1 | 7.31 |
| CHEMBL559260 | — | — | 1 | 6.85 |
| CHEMBL557740 | — | — | 1 | 6.82 |
| CHEMBL558025 | — | — | 1 | 6.79 |
| CHEMBL563760 | — | — | 1 | 6.75 |
| CHEMBL550881 | — | — | 1 | 6.71 |
| CHEMBL564509 | — | — | 1 | 6.70 |
| CHEMBL561750 | — | — | 1 | 6.56 |
| CHEMBL550740 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282199 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL557330 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL204171 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL497749 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL561346 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL559260 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL557740 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL558025 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL563760 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL550881 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL564509 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL561750 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL550740 | — | Ki | = | 339.0 | nM | 6.47 |