Assay Detail
Functional
CHEMBL1059362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma assessed as luciferase activity by transactivation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.62 | 4.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583378 | — | — | 1 | 4.81 |
| CHEMBL575075 | — | — | 1 | 4.72 |
| CHEMBL573966 | — | — | 1 | 4.65 |
| CHEMBL486176 | PSEUDOBAPTOGENIN | — | 1 | 4.57 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583378 | — | EC50 | = | 15380.0 | nM | 4.81 |
| CHEMBL575075 | — | EC50 | = | 18860.0 | nM | 4.72 |
| CHEMBL573966 | — | EC50 | = | 22290.0 | nM | 4.65 |
| CHEMBL486176 | PSEUDOBAPTOGENIN | EC50 | = | 26940.0 | nM | 4.57 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 43710.0 | nM | 4.36 |