Assay Detail
Binding
CHEMBL1059429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]KA from KA receptor in rat cortical synaptosomes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.17 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28472 | — | — | 1 | 5.80 |
| CHEMBL553028 | — | — | 1 | 5.08 |
| CHEMBL27130 | — | — | 1 | 4.64 |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28472 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL553028 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL27130 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |