Assay Detail
Binding
CHEMBL1059435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AMPA from rat recombinant GluR1 flop isoform expressed in baculovirus infected Sf9 cells
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.00 | 6.63 |
| pKi | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28472 | — | — | 2 | 6.63 |
| CHEMBL553028 | — | — | 2 | 5.81 |
| CHEMBL27130 | — | — | 2 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28472 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL553028 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL27130 | — | Ki | = | 2780.0 | nM | 5.56 |
| CHEMBL27130 | — | pKi | = | 3.526 | nM | - |
| CHEMBL28472 | — | pKi | = | 2.364 | nM | - |
| CHEMBL553028 | — | pKi | = | 3.177 | nM | - |