Assay Detail
Functional
CHEMBL1059697
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Cytotoxicity against human MDA-MB-468 cells expressing estrogen receptor after 5 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.37 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 6.19 |
| CHEMBL551801 | — | — | 1 | 5.94 |
| CHEMBL553707 | — | — | 1 | 5.26 |
| CHEMBL171376 | — | — | 1 | 5.14 |
| CHEMBL554374 | — | — | 1 | 4.99 |
| CHEMBL541681 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL551801 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL553707 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL171376 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL554374 | — | IC50 | = | 10260.0 | nM | 4.99 |
| CHEMBL541681 | — | IC50 | = | 19340.0 | nM | 4.71 |