Assay Detail
Binding
CHEMBL1059720
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Inhibition of PDE11
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.88 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551052 | — | — | 1 | 6.46 |
| CHEMBL551250 | — | — | 1 | 5.86 |
| CHEMBL550851 | — | — | 1 | 5.83 |
| CHEMBL564374 | — | — | 1 | 5.81 |
| CHEMBL551050 | — | — | 1 | 5.45 |
| CHEMBL560516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551052 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL551250 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL550851 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL564374 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL551050 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL560516 | — | IC50 | > | 1990.0 | nM | - |