Assay Detail
Functional
CHEMBL1059965
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Antiviral activity against HCV by viral replicon assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.99 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73809 | — | — | 1 | 6.52 |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73809 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | EC50 | = | 3500.0 | nM | 5.46 |