Assay Detail
Functional
CHEMBL1060375
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Cytotoxicity against human PC3 cells after 72 hrs by CellTitter-Glo luminescent cell viability assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.39 | 6.07 |
| EC50 | 2 | 5.73 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564481 | CYCLODOXAZOSIN | — | 2 | 6.07 |
| CHEMBL558890 | — | — | 1 | 5.99 |
| CHEMBL561851 | — | — | 1 | 5.08 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 2 | 4.41 |
| CHEMBL549764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564481 | CYCLODOXAZOSIN | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL558890 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL564481 | CYCLODOXAZOSIN | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL561851 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL707 | DOXAZOSIN | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL549764 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL707 | DOXAZOSIN | EC50 | > | 100000.0 | nM | - |