Assay Detail
Functional
CHEMBL1060382
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Induction of apoptosis in human NHDF cells assessed as caspase 3/7 activation after 24 hrs Caspase-Glo 3/7 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NHDF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.75 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561851 | — | — | 1 | 5.00 |
| CHEMBL549764 | — | — | 1 | 5.00 |
| CHEMBL564481 | CYCLODOXAZOSIN | — | 1 | 5.00 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561851 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL549764 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL564481 | CYCLODOXAZOSIN | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL707 | DOXAZOSIN | EC50 | = | 100000.0 | nM | 4.00 |