Assay Detail
Functional
CHEMBL1060409
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Cytotoxicity against human MDA-MB-468 cells by SRB assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.37 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 8.00 |
| CHEMBL562667 | — | — | 1 | 6.75 |
| CHEMBL559450 | — | — | 1 | 6.68 |
| CHEMBL560360 | — | — | 1 | 5.94 |
| CHEMBL444360 | EPITRIPTOIIDE | — | 1 | 5.88 |
| CHEMBL562027 | — | — | 1 | 5.72 |
| CHEMBL561903 | — | — | 1 | 5.62 |
| CHEMBL563410 | — | — | 1 | - |
| CHEMBL2092723 | — | — | 2 | - |
| CHEMBL552097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL562667 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL559450 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL560360 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL444360 | EPITRIPTOIIDE | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL562027 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL561903 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL563410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092723 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092723 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL552097 | — | IC50 | > | 100000.0 | nM | - |