Assay Detail
Functional
CHEMBL1060554
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Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.95 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554717 | — | — | 1 | 5.77 |
| CHEMBL555913 | — | — | 1 | 5.75 |
| CHEMBL555912 | — | — | 1 | 5.50 |
| CHEMBL550591 | — | — | 1 | 5.49 |
| CHEMBL539439 | — | — | 1 | 5.42 |
| CHEMBL540181 | — | — | 1 | 5.30 |
| CHEMBL563141 | — | — | 1 | 5.26 |
| CHEMBL563121 | — | — | 1 | 5.22 |
| CHEMBL550052 | — | — | 1 | 4.86 |
| CHEMBL266487 | RO-316233 | — | 1 | 4.76 |
| CHEMBL563874 | — | — | 1 | 4.67 |
| CHEMBL563533 | — | — | 1 | 4.58 |
| CHEMBL563685 | — | — | 1 | 4.50 |
| CHEMBL558249 | — | — | 1 | 4.44 |
| CHEMBL562709 | — | — | 1 | 4.33 |
| CHEMBL564091 | — | — | 1 | 4.30 |
| CHEMBL560585 | — | — | 1 | 4.07 |
| CHEMBL552791 | — | — | 1 | - |
| CHEMBL554156 | — | — | 1 | - |
| CHEMBL562947 | — | — | 1 | - |
| CHEMBL564815 | — | — | 1 | - |
| CHEMBL564033 | — | — | 1 | - |
| CHEMBL561730 | — | — | 1 | - |
| CHEMBL563560 | — | — | 1 | - |
| CHEMBL559792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554717 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL555913 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL555912 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL550591 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL539439 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL540181 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL563141 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL563121 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL550052 | — | IC50 | = | 13760.0 | nM | 4.86 |
| CHEMBL266487 | RO-316233 | IC50 | = | 17460.0 | nM | 4.76 |
| CHEMBL563874 | — | IC50 | = | 21560.0 | nM | 4.67 |
| CHEMBL563533 | — | IC50 | = | 26430.0 | nM | 4.58 |
| CHEMBL563685 | — | IC50 | = | 31750.0 | nM | 4.50 |
| CHEMBL558249 | — | IC50 | = | 36560.0 | nM | 4.44 |
| CHEMBL562709 | — | IC50 | = | 46730.0 | nM | 4.33 |
| CHEMBL564091 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL560585 | — | IC50 | = | 85780.0 | nM | 4.07 |
| CHEMBL552791 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL554156 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL562947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL564815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL564033 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL561730 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL563560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559792 | — | IC50 | > | 100000.0 | nM | - |