Assay Detail
Binding
CHEMBL1060792
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Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 mins
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.71 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552173 | — | — | 1 | 9.70 |
| CHEMBL557445 | — | — | 1 | 9.22 |
| CHEMBL550800 | — | — | 1 | 9.00 |
| CHEMBL552126 | — | — | 1 | 9.00 |
| CHEMBL552270 | — | — | 1 | 8.70 |
| CHEMBL552269 | — | — | 1 | 8.54 |
| CHEMBL560271 | — | — | 1 | 8.52 |
| CHEMBL550172 | — | — | 1 | 8.52 |
| CHEMBL562268 | — | — | 1 | 8.40 |
| CHEMBL561588 | — | — | 1 | 8.40 |
| CHEMBL564822 | — | — | 1 | 8.05 |
| CHEMBL557652 | — | — | 1 | 8.05 |
| CHEMBL561073 | — | — | 1 | 8.00 |
| CHEMBL559108 | — | — | 1 | 7.96 |
| CHEMBL561530 | — | — | 1 | 7.09 |
| CHEMBL556495 | — | — | 1 | 6.90 |
| CHEMBL562988 | — | — | 1 | 6.84 |
| CHEMBL562737 | — | — | 1 | 6.04 |
| CHEMBL559739 | — | — | 1 | 5.91 |
| CHEMBL564721 | — | — | 1 | 5.85 |
| CHEMBL562592 | — | — | 1 | 5.67 |
| CHEMBL558451 | — | — | 1 | 5.36 |
| CHEMBL559107 | — | — | 1 | - |
| CHEMBL560193 | — | — | 1 | - |
| CHEMBL564689 | — | — | 1 | - |
| CHEMBL564046 | — | — | 1 | - |
| CHEMBL550726 | — | — | 1 | - |
| CHEMBL562531 | — | — | 1 | - |
| CHEMBL558808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552173 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL557445 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL550800 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL552126 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL552270 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL552269 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL560271 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL550172 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL562268 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL561588 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL564822 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL557652 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL561073 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL559108 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL561530 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL556495 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL562988 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL562737 | — | IC50 | = | 915.0 | nM | 6.04 |
| CHEMBL559739 | — | IC50 | = | 1218.0 | nM | 5.91 |
| CHEMBL564721 | — | IC50 | = | 1402.0 | nM | 5.85 |
| CHEMBL562592 | — | IC50 | = | 2162.0 | nM | 5.67 |
| CHEMBL558451 | — | IC50 | = | 4377.0 | nM | 5.36 |
| CHEMBL559107 | — | IC50 | - | — | - | |
| CHEMBL560193 | — | IC50 | > | 9999.0 | nM | - |
| CHEMBL564689 | — | IC50 | - | — | - | |
| CHEMBL564046 | — | IC50 | > | 9999.0 | nM | - |
| CHEMBL550726 | — | IC50 | - | — | - | |
| CHEMBL562531 | — | IC50 | - | — | - | |
| CHEMBL558808 | — | IC50 | - | — | - |