Assay Detail
Binding
CHEMBL1060803
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Inhibition of human SCD1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-A |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.41 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557445 | — | — | 1 | 8.10 |
| CHEMBL561588 | — | — | 1 | 8.05 |
| CHEMBL552126 | — | — | 1 | 7.89 |
| CHEMBL550800 | — | — | 1 | 7.89 |
| CHEMBL552270 | — | — | 1 | 7.77 |
| CHEMBL552173 | — | — | 1 | 7.58 |
| CHEMBL559108 | — | — | 1 | 7.47 |
| CHEMBL557652 | — | — | 1 | 7.47 |
| CHEMBL562268 | — | — | 1 | 7.23 |
| CHEMBL552269 | — | — | 1 | 6.94 |
| CHEMBL556495 | — | — | 1 | 6.37 |
| CHEMBL561530 | — | — | 1 | 6.19 |
| CHEMBL564689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557445 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL561588 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL552126 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL550800 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL552270 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL552173 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL559108 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL557652 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL562268 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL552269 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL556495 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL561530 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL564689 | — | IC50 | - | — | - |