Assay Detail
Binding
CHEMBL1060930
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550818 | — | — | 1 | 7.54 |
| CHEMBL94454 | MIZOLASTINE | 4.0 | 1 | 6.36 |
| CHEMBL556450 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550818 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL94454 | MIZOLASTINE | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL556450 | — | IC50 | = | 809.0 | nM | 6.09 |