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Assay Detail

CHEMBL1061464

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mushroom tyrosinase activity after 90 mins by spectrophotometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Tyrosinase (CHEMBL3318)
Type SINGLE PROTEIN
Organism Agaricus bisporus

Publication

Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.
Ng LT, Ko HH, Lu TM.
Bioorg Med Chem (2009) 17 : 4360 -4366
PubMed 19481947 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.37 4.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL541247 1 4.37
CHEMBL287556 KOJIC ACID 1 -
CHEMBL395753 1 -
CHEMBL557305 1 -
CHEMBL563494 1 -
CHEMBL243376 1 -
CHEMBL267605 1 -
CHEMBL559867 1 -
CHEMBL550181 1 -
CHEMBL557103 1 -
CHEMBL193200 1 -
CHEMBL241858 ONONETIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL541247 IC50 = 43100.0 nM 4.37
CHEMBL287556 KOJIC ACID IC50 = 225140.0 nM -
CHEMBL395753 IC50 > 300000.0 nM -
CHEMBL557305 IC50 = 213860.0 nM -
CHEMBL563494 IC50 = 131530.0 nM -
CHEMBL243376 IC50 > 300000.0 nM -
CHEMBL267605 IC50 = 203320.0 nM -
CHEMBL559867 IC50 = 144190.0 nM -
CHEMBL550181 IC50 = 167970.0 nM -
CHEMBL557103 IC50 = 209140.0 nM -
CHEMBL193200 IC50 = 135910.0 nM -
CHEMBL241858 ONONETIN IC50 = 160370.0 nM -