Assay Detail
Binding
CHEMBL1061783
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Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.39 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363559 | DEOXYTHYMIDINE_TRIPHOSPHATE | — | 1 | 5.58 |
| CHEMBL560403 | DEOXYCYTIDINE TRIPHOSPHATE | — | 1 | 5.52 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.46 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363559 | DEOXYTHYMIDINE_TRIPHOSPHATE | Kd | = | 2650.0 | nM | 5.58 |
| CHEMBL560403 | DEOXYCYTIDINE TRIPHOSPHATE | Kd | = | 2990.0 | nM | 5.52 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Kd | = | 9800.0 | nM | 5.01 |