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Assay Detail

CHEMBL1061809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Penicillium digitatum CYP51 expressed in Escherichia coli by UV-visible spectrophotometry
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Penicillium digitatum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Organocatalytic synthesis and sterol 14alpha-demethylase binding interactions of enantioriched 3-(1H-1,2,4-triazol-1-yl)butyl benzoates.
Ming ZH, Xu SZ, Zhou L, Ding MW, Yang JY, Yang S, Xiao WJ.
Bioorg Med Chem Lett (2009) 19 : 3938 -3940
PubMed 19329311 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 19 6.02 6.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL551746 DINICONAZOLE 1 6.61
CHEMBL549384 1 6.47
CHEMBL569373 1 6.34
CHEMBL549859 1 6.33
CHEMBL556651 1 6.25
CHEMBL571907 1 6.24
CHEMBL551538 1 6.17
CHEMBL556719 1 6.13
CHEMBL520897 TRIADIMEFON 1 6.03
CHEMBL560942 1 6.01
CHEMBL556859 1 6.00
CHEMBL562084 1 5.95
CHEMBL556510 1 5.93
CHEMBL562085 1 5.86
CHEMBL556443 1 5.85
CHEMBL549452 1 5.79
CHEMBL562205 1 5.76
CHEMBL563854 1 5.63
CHEMBL562284 1 4.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL551746 DINICONAZOLE Kd = 247.3 nM 6.61
CHEMBL549384 Kd = 338.1 nM 6.47
CHEMBL569373 Kd = 452.4 nM 6.34
CHEMBL549859 Kd = 472.4 nM 6.33
CHEMBL556651 Kd = 560.0 nM 6.25
CHEMBL571907 Kd = 580.1 nM 6.24
CHEMBL551538 Kd = 682.4 nM 6.17
CHEMBL556719 Kd = 742.9 nM 6.13
CHEMBL520897 TRIADIMEFON Kd = 935.5 nM 6.03
CHEMBL560942 Kd = 973.4 nM 6.01
CHEMBL556859 Kd = 988.1 nM 6.00
CHEMBL562084 Kd = 1116.3 nM 5.95
CHEMBL556510 Kd = 1182.4 nM 5.93
CHEMBL562085 Kd = 1375.9 nM 5.86
CHEMBL556443 Kd = 1417.3 nM 5.85
CHEMBL549452 Kd = 1618.3 nM 5.79
CHEMBL562205 Kd = 1739.2 nM 5.76
CHEMBL563854 Kd = 2356.8 nM 5.63
CHEMBL562284 Kd = 10490.3 nM 4.98