Assay Detail
Binding
CHEMBL1061942
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Inhibition of PIM1 in the presence of 20uM ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The selectivity of protein kinase inhibitors: a further update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.48 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191384 | — | — | 1 | 7.10 |
| CHEMBL1880739 | GW305074X | — | 1 | 6.77 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.09 |
| CHEMBL79004 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191384 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1880739 | GW305074X | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL98350 | LY-294002 | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL79004 | — | IC50 | = | 1100.0 | nM | 5.96 |