Assay Detail
Functional
CHEMBL1062033
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Inhibition of HCT-8 clonogenic growth in soft agar without pretreatment
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574058 | — | — | 1 | 6.58 |
| CHEMBL574059 | — | — | 1 | 5.94 |
| CHEMBL106772 | — | — | 1 | 5.90 |
| CHEMBL578006 | — | — | 1 | 5.90 |
| CHEMBL386051 | — | — | 1 | 5.89 |
| CHEMBL327127 | — | — | 1 | - |
| CHEMBL573820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574058 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL574059 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL106772 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL578006 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL386051 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL327127 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL573820 | — | IC50 | > | 5000.0 | nM | - |