Assay Detail
Functional
CHEMBL1062034
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Inhibition of HT-29 clonogenic growth in soft agar without pretreatment
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.73 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578006 | — | — | 1 | 6.00 |
| CHEMBL386051 | — | — | 1 | 5.89 |
| CHEMBL106772 | — | — | 1 | 5.86 |
| CHEMBL574058 | — | — | 1 | 5.82 |
| CHEMBL574059 | — | — | 1 | 5.81 |
| CHEMBL327127 | — | — | 1 | 4.99 |
| CHEMBL573820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578006 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL386051 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL106772 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL574058 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL574059 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL327127 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL573820 | — | IC50 | < | 5000.0 | nM | - |