Assay Detail
Binding
CHEMBL1062035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against PKA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.16 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406821 | — | — | 1 | 6.47 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.34 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 5.66 |
| CHEMBL559147 | Y-27632 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406821 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL38380 | FASUDIL | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL1233300 | HYDROXYFASUDIL | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL559147 | Y-27632 | Ki | > | 5000.0 | nM | - |