Assay Detail
Binding
CHEMBL1062055
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Inhibition of MAO-A from Wistar rat brain by radioenzymatic assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.96 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572768 | — | — | 1 | 6.70 |
| CHEMBL575093 | — | — | 1 | 6.33 |
| CHEMBL575931 | — | — | 1 | 6.30 |
| CHEMBL572828 | — | — | 1 | 5.84 |
| CHEMBL575938 | — | — | 1 | 5.70 |
| CHEMBL572534 | — | — | 1 | 5.70 |
| CHEMBL573051 | — | — | 1 | 5.60 |
| CHEMBL573300 | — | — | 1 | 5.55 |
| CHEMBL574191 | — | — | 1 | 5.37 |
| CHEMBL572533 | — | — | 1 | 5.36 |
| CHEMBL573301 | — | — | 1 | 5.27 |
| CHEMBL593763 | — | — | 1 | 5.23 |
| CHEMBL575937 | — | — | 1 | 5.20 |
| CHEMBL574419 | — | — | 1 | 5.10 |
| CHEMBL575285 | — | — | 1 | 4.87 |
| CHEMBL573052 | — | — | 1 | 4.81 |
| CHEMBL573985 | — | — | 1 | 4.68 |
| CHEMBL575734 | — | — | 1 | 4.65 |
| CHEMBL577614 | — | — | 1 | 4.64 |
| CHEMBL573755 | — | — | 1 | 4.64 |
| CHEMBL585360 | — | — | 1 | 4.59 |
| CHEMBL575738 | — | — | 1 | 4.58 |
| CHEMBL573986 | — | — | 1 | 4.58 |
| CHEMBL575486 | — | — | 1 | 4.50 |
| CHEMBL583128 | — | — | 1 | 4.46 |
| CHEMBL574860 | — | — | 1 | 4.29 |
| CHEMBL583587 | — | — | 1 | 4.16 |
| CHEMBL573988 | — | — | 1 | 4.13 |
| CHEMBL575735 | — | — | 1 | 4.04 |
| CHEMBL577175 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572768 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL575093 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL575931 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL572828 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL575938 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL572534 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL573051 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL573300 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL574191 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL572533 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL573301 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL593763 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL575937 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL574419 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL575285 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL573052 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL573985 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL575734 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL577614 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL573755 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL585360 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL575738 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL573986 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL575486 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL583128 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL574860 | — | IC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL583587 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL573988 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL575735 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL577175 | — | IC50 | = | 99800.0 | nM | 4.00 |
| CHEMBL584377 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL574859 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL575907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL575737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL575074 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL575908 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL573522 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL577616 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL575522 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL584607 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL575521 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL574420 | — | IC50 | > | 100000.0 | nM | - |