Assay Detail
Functional
CHEMBL1062604
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Cytotoxic activity against human REH cells after 48 hrs by fluorescent resazurin dye assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | REH |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.90 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203172 | — | — | 1 | 5.39 |
| CHEMBL203173 | — | — | 1 | 4.81 |
| CHEMBL380627 | — | — | 1 | 4.71 |
| CHEMBL204347 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203172 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL203173 | — | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL380627 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL204347 | — | EC50 | = | 21000.0 | nM | 4.68 |