Assay Detail
Binding
CHEMBL1062884
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Inhibition of IKK-beta in the presence of 5uM ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The selectivity of protein kinase inhibitors: a further update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.96 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79004 | — | — | 1 | 6.60 |
| CHEMBL193093 | — | — | 1 | 5.70 |
| CHEMBL249697 | BMS-345541 | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79004 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL193093 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL249697 | BMS-345541 | IC50 | = | 2600.0 | nM | 5.58 |