Assay Detail
Binding
CHEMBL1063153
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Inhibition of human NAD kinase by modified HPLC based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.58 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560315 | — | — | 1 | 5.22 |
| CHEMBL562056 | — | — | 1 | 5.22 |
| CHEMBL538665 | — | — | 1 | 4.35 |
| CHEMBL561654 | — | — | 1 | 4.06 |
| CHEMBL233434 | BENZAMIDEADENINEDINUCLEOSIDE | — | 1 | 4.05 |
| CHEMBL550645 | — | — | 1 | - |
| CHEMBL559921 | — | — | 1 | - |
| CHEMBL558497 | — | — | 1 | - |
| CHEMBL550705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560315 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL562056 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL538665 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL561654 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL233434 | BENZAMIDEADENINEDINUCLEOSIDE | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL550645 | — | IC50 | - | — | - | |
| CHEMBL559921 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL558497 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL550705 | — | IC50 | - | — | - |