Assay Detail
Binding
CHEMBL1063154
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Inhibition of human IMPDH
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.93 | 9.00 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392203 | — | — | 1 | 9.00 |
| CHEMBL235533 | — | — | 1 | 8.00 |
| CHEMBL394277 | — | — | 1 | 7.70 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | — | 1 | 7.00 |
| CHEMBL561654 | — | — | 1 | - |
| CHEMBL550645 | — | — | 1 | - |
| CHEMBL559921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392203 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL235533 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL394277 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL561654 | — | Inhibition | - | % | - | |
| CHEMBL550645 | — | Inhibition | - | % | - | |
| CHEMBL559921 | — | Inhibition | - | % | - |