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Assay Detail

CHEMBL1063293

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Binding
Inhibition of AP-1/NF-kappaB transfected in human jurkat T cells assessed as inhibition of transcriptional activation
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type Jurkat
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

3D-QSAR studies on the inhibitors of AP-1 and NF-kappaB mediated transcriptional activation.
Qin J, Liu H, Li J, Ren Y, Yao X, Liu M.
Eur J Med Chem (2009) 44 : 2888 -2895
PubMed 19128859 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 6.31 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL337665 — — 1 8.52
CHEMBL129857 AS-602868 1.0 1 8.10
CHEMBL133412 — — 1 8.00
CHEMBL337640 — — 1 7.70
CHEMBL130406 — — 1 7.70
CHEMBL131953 — — 1 7.70
CHEMBL133622 — — 1 7.70
CHEMBL43549 — — 1 7.70
CHEMBL130204 — — 1 7.52
CHEMBL335904 — — 1 7.40
CHEMBL336770 — — 1 7.40
CHEMBL130752 — — 1 7.30
CHEMBL131132 — — 1 7.30
CHEMBL133379 — — 1 7.30
CHEMBL130837 — — 1 7.22
CHEMBL134245 — — 1 7.10
CHEMBL133245 — — 1 7.00
CHEMBL335612 — — 1 7.00
CHEMBL42952 — — 1 7.00
CHEMBL130007 — — 1 7.00
CHEMBL43610 — — 1 7.00
CHEMBL129940 — — 1 6.70
CHEMBL43251 — — 1 6.70
CHEMBL295508 — — 1 6.70
CHEMBL43534 — — 1 6.70
CHEMBL295192 — — 1 6.70
CHEMBL133631 — — 1 6.70
CHEMBL42650 — — 1 6.70
CHEMBL44525 — — 1 6.70
CHEMBL45261 — — 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL337665 — IC50 = 2.999 nM 8.52
CHEMBL129857 AS-602868 IC50 = 7.998 nM 8.10
CHEMBL133412 — IC50 = 10.0 nM 8.00
CHEMBL337640 — IC50 = 20.0 nM 7.70
CHEMBL130406 — IC50 = 20.0 nM 7.70
CHEMBL131953 — IC50 = 20.0 nM 7.70
CHEMBL133622 — IC50 = 20.0 nM 7.70
CHEMBL43549 — IC50 = 20.0 nM 7.70
CHEMBL130204 — IC50 = 29.99 nM 7.52
CHEMBL335904 — IC50 = 39.99 nM 7.40
CHEMBL336770 — IC50 = 39.99 nM 7.40
CHEMBL133379 — IC50 = 50.0 nM 7.30
CHEMBL131132 — IC50 = 50.0 nM 7.30
CHEMBL130752 — IC50 = 50.0 nM 7.30
CHEMBL130837 — IC50 = 59.98 nM 7.22
CHEMBL134245 — IC50 = 79.98 nM 7.10
CHEMBL133245 — IC50 = 100.0 nM 7.00
CHEMBL335612 — IC50 = 100.0 nM 7.00
CHEMBL42952 — IC50 = 100.0 nM 7.00
CHEMBL130007 — IC50 = 100.0 nM 7.00
CHEMBL43610 — IC50 = 100.0 nM 7.00
CHEMBL44525 — IC50 = 199.99 nM 6.70
CHEMBL42650 — IC50 = 199.99 nM 6.70
CHEMBL133631 — IC50 = 199.99 nM 6.70
CHEMBL295192 — IC50 = 199.99 nM 6.70
CHEMBL295508 — IC50 = 199.99 nM 6.70
CHEMBL43251 — IC50 = 199.99 nM 6.70
CHEMBL129940 — IC50 = 199.99 nM 6.70
CHEMBL43534 — IC50 = 199.99 nM 6.70
CHEMBL45261 — IC50 = 299.92 nM 6.52
CHEMBL42204 — IC50 = 299.92 nM 6.52
CHEMBL296695 — IC50 = 299.92 nM 6.52
CHEMBL296202 — IC50 = 299.92 nM 6.52
CHEMBL43259 — IC50 = 299.92 nM 6.52
CHEMBL295050 — IC50 = 399.94 nM 6.40
CHEMBL336408 — IC50 = 399.94 nM 6.40
CHEMBL42079 — IC50 = 699.84 nM 6.16
CHEMBL43451 — IC50 = 699.84 nM 6.16
CHEMBL297842 — IC50 = 899.5 nM 6.05
CHEMBL42547 — IC50 = 1000.0 nM 6.00
CHEMBL42235 — IC50 = 1000.0 nM 6.00
CHEMBL336177 — IC50 = 1000.0 nM 6.00
CHEMBL42719 — IC50 = 1000.0 nM 6.00
CHEMBL46509 — IC50 = 1000.0 nM 6.00
CHEMBL413028 — IC50 = 1000.0 nM 6.00
CHEMBL44089 — IC50 = 1999.86 nM 5.70
CHEMBL416627 — IC50 = 1999.86 nM 5.70
CHEMBL43388 — IC50 = 1999.86 nM 5.70
CHEMBL43550 — IC50 = 2999.16 nM 5.52
CHEMBL297420 — IC50 = 3999.45 nM 5.40