Assay Detail
Binding
CHEMBL1064061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]nisoxetine from human NET expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234706 | — | — | 1 | 6.41 |
| CHEMBL552167 | — | — | 1 | 5.10 |
| CHEMBL196468 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234706 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL552167 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL196468 | — | IC50 | = | 9200.0 | nM | 5.04 |