Assay Detail
Binding
CHEMBL1064148
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Inhibition of wild type HCV NS5B polymerase assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.81 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373691 | PSI-6130-TP | -1.0 | 1 | 7.23 |
| CHEMBL486231 | GS-461203 | -1.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373691 | PSI-6130-TP | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL486231 | GS-461203 | Ki | = | 420.0 | nM | 6.38 |