Assay Detail
Binding
CHEMBL1064296
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Binding affinity to human adenosine A3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.50 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589080 | — | — | 1 | 9.40 |
| CHEMBL305322 | — | — | 1 | 7.09 |
| CHEMBL592435 | DERENOFYLLINE | 2.0 | 1 | 6.70 |
| CHEMBL60156 | — | — | 1 | 6.17 |
| CHEMBL414157 | TONAPOFYLLINE | 3.0 | 1 | 5.00 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589080 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL305322 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL592435 | DERENOFYLLINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL60156 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL414157 | TONAPOFYLLINE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 22300.0 | nM | 4.65 |