Assay Detail
Binding
CHEMBL1064652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine tubulin polymerization
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.98 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596245 | — | — | 1 | 6.37 |
| CHEMBL592982 | — | — | 1 | 6.26 |
| CHEMBL595360 | — | — | 1 | 6.24 |
| CHEMBL608716 | — | — | 1 | 6.16 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.00 |
| CHEMBL603631 | — | — | 1 | 5.96 |
| CHEMBL594158 | — | — | 1 | 5.96 |
| CHEMBL593009 | — | — | 1 | 5.92 |
| CHEMBL596488 | — | — | 1 | 5.75 |
| CHEMBL612136 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596245 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL592982 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL595360 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL608716 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL603631 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL594158 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL593009 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL596488 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL612136 | — | IC50 | = | 6900.0 | nM | 5.16 |