Assay Detail
Functional
CHEMBL1064689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells after 72 hrs by methylene blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of epothilone A dimeric compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.67 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | — | 1 | 8.60 |
| CHEMBL594876 | — | — | 1 | 6.49 |
| CHEMBL595070 | — | — | 1 | 6.45 |
| CHEMBL595071 | — | — | 1 | 6.42 |
| CHEMBL594716 | — | — | 1 | 6.38 |
| CHEMBL595020 | — | — | 1 | 6.37 |
| CHEMBL595072 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL594876 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL595070 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL595071 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL594716 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL595020 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL595072 | — | IC50 | = | 1033.0 | nM | 5.99 |