Assay Detail
Binding
CHEMBL1064844
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Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.59 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590547 | — | — | 1 | 9.77 |
| CHEMBL2372427 | — | — | 1 | 9.46 |
| CHEMBL590609 | — | — | 1 | 9.43 |
| CHEMBL590646 | — | — | 1 | 9.19 |
| CHEMBL590654 | — | — | 1 | 8.29 |
| CHEMBL590583 | — | — | 1 | 8.19 |
| CHEMBL590715 | — | — | 1 | 8.08 |
| CHEMBL590628 | — | — | 1 | 7.64 |
| CHEMBL590716 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590547 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL2372427 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL590609 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL590646 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL590654 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL590583 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL590715 | — | IC50 | = | 8.39 | nM | 8.08 |
| CHEMBL590628 | — | IC50 | = | 22.95 | nM | 7.64 |
| CHEMBL590716 | — | IC50 | = | 59.9 | nM | 7.22 |