Assay Detail
Binding
CHEMBL1064845
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Inhibition of integrin alphaVbeta5 receptor-mediated adhesion of human A2780 cells to vitronectin after 1 hr by toluidine blue staining
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.18 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590583 | — | — | 1 | 5.75 |
| CHEMBL590609 | — | — | 1 | 5.51 |
| CHEMBL590547 | — | — | 1 | 5.28 |
| CHEMBL590716 | — | — | 1 | 5.17 |
| CHEMBL590654 | — | — | 1 | 5.02 |
| CHEMBL590646 | — | — | 1 | 4.93 |
| CHEMBL2372427 | — | — | 1 | 4.91 |
| CHEMBL590628 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590583 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL590609 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL590547 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL590716 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL590654 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL590646 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2372427 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL590628 | — | IC50 | = | 12900.0 | nM | 4.89 |