Assay Detail
Binding
CHEMBL1064847
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Inhibition of integrin alphaVbeta3 receptor-mediated adhesion of human A498 cells to vitronectin after 1 hr by toluidine blue staining
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A498 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.14 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590583 | — | — | 1 | 5.51 |
| CHEMBL590609 | — | — | 1 | 5.43 |
| CHEMBL590715 | — | — | 1 | 5.27 |
| CHEMBL590547 | — | — | 1 | 5.19 |
| CHEMBL2372427 | — | — | 1 | 4.97 |
| CHEMBL590654 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590583 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL590609 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL590715 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL590547 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2372427 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL590654 | — | IC50 | = | 34000.0 | nM | 4.47 |