Assay Detail
Functional
CHEMBL1065376
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Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.24 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596222 | — | — | 1 | 5.66 |
| CHEMBL595800 | — | — | 1 | 5.46 |
| CHEMBL596441 | — | — | 1 | 4.60 |
| CHEMBL594165 | ARTANIN | — | 1 | - |
| CHEMBL607537 | 5,6,7-TRIMETHOXYCOUMARIN | — | 1 | - |
| CHEMBL611815 | — | — | 1 | - |
| CHEMBL593707 | — | — | 1 | - |
| CHEMBL595799 | — | — | 1 | - |
| CHEMBL595798 | AYAPIN | — | 1 | - |
| CHEMBL596378 | — | — | 1 | - |
| CHEMBL607554 | — | — | 1 | - |
| CHEMBL594418 | — | — | 1 | - |
| CHEMBL611219 | — | — | 1 | - |
| CHEMBL596030 | — | — | 1 | - |
| CHEMBL611651 | — | — | 1 | - |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
| CHEMBL607536 | PRENYLETIN | — | 1 | - |
| CHEMBL594886 | PRENYLETIN 6-METHYL ETHER | — | 1 | - |
| CHEMBL594887 | — | — | 1 | - |
| CHEMBL611349 | FRAXINOL | — | 1 | - |
| CHEMBL595334 | LEPTODACTYLONE | — | 1 | - |
| CHEMBL596221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596222 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL595800 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL596441 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL594165 | ARTANIN | IC50 | = | 177300.0 | nM | - |
| CHEMBL607537 | 5,6,7-TRIMETHOXYCOUMARIN | IC50 | = | 182100.0 | nM | - |
| CHEMBL611815 | — | IC50 | = | 191900.0 | nM | - |
| CHEMBL593707 | — | IC50 | = | 226900.0 | nM | - |
| CHEMBL595799 | — | IC50 | = | 255400.0 | nM | - |
| CHEMBL595798 | AYAPIN | IC50 | > | 400000.0 | nM | - |
| CHEMBL596378 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL607554 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL594418 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL611219 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL596030 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL611651 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL6466 | COUMARIN | IC50 | > | 400000.0 | nM | - |
| CHEMBL607536 | PRENYLETIN | IC50 | > | 400000.0 | nM | - |
| CHEMBL594886 | PRENYLETIN 6-METHYL ETHER | IC50 | > | 400000.0 | nM | - |
| CHEMBL594887 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL611349 | FRAXINOL | IC50 | > | 400000.0 | nM | - |
| CHEMBL595334 | LEPTODACTYLONE | IC50 | > | 400000.0 | nM | - |
| CHEMBL596221 | — | IC50 | > | 400000.0 | nM | - |