Assay Detail
Binding
CHEMBL1065458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycine receptor subunit alpha-1 (CHEMBL3246) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.17 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084712 | — | — | 1 | 7.47 |
| CHEMBL3084718 | — | — | 1 | 7.38 |
| CHEMBL3084707 | — | — | 1 | 7.10 |
| CHEMBL3084711 | — | — | 1 | 7.00 |
| CHEMBL3084716 | — | — | 1 | 6.89 |
| CHEMBL3084714 | — | — | 1 | 6.78 |
| CHEMBL3084706 | — | — | 1 | 6.63 |
| CHEMBL3084708 | — | — | 1 | 5.80 |
| CHEMBL3084713 | — | — | 1 | 5.72 |
| CHEMBL3084717 | — | — | 1 | 5.72 |
| CHEMBL3084710 | — | — | 1 | 5.37 |
| CHEMBL3084705 | — | — | 1 | 5.33 |
| CHEMBL3084704 | — | — | 1 | 5.25 |
| CHEMBL3084709 | — | — | 1 | 5.12 |
| CHEMBL3084715 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084712 | — | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL3084718 | — | IC50 | = | 41.69 | nM | 7.38 |
| CHEMBL3084707 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3084711 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3084716 | — | IC50 | = | 128.82 | nM | 6.89 |
| CHEMBL3084714 | — | IC50 | = | 165.96 | nM | 6.78 |
| CHEMBL3084706 | — | IC50 | = | 234.42 | nM | 6.63 |
| CHEMBL3084708 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3084713 | — | IC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL3084717 | — | IC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL3084710 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL3084705 | — | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL3084704 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL3084709 | — | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL3084715 | — | IC50 | = | 11220.18 | nM | 4.95 |