Assay Detail
Binding
CHEMBL1065459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycine receptor subunit alpha-1 (CHEMBL3246) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.42 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084708 | — | — | 1 | 7.99 |
| CHEMBL3084712 | — | — | 1 | 7.94 |
| CHEMBL3084715 | — | — | 1 | 7.47 |
| CHEMBL3084704 | — | — | 1 | 7.30 |
| CHEMBL3084710 | — | — | 1 | 7.23 |
| CHEMBL3084705 | — | — | 1 | 7.22 |
| CHEMBL3084713 | — | — | 1 | 7.14 |
| CHEMBL3084717 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084708 | — | IC50 | = | 10.23 | nM | 7.99 |
| CHEMBL3084712 | — | IC50 | = | 11.48 | nM | 7.94 |
| CHEMBL3084715 | — | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL3084704 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3084710 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL3084705 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL3084713 | — | IC50 | = | 72.44 | nM | 7.14 |
| CHEMBL3084717 | — | IC50 | = | 89.13 | nM | 7.05 |