Assay Detail
Binding
CHEMBL1065460
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]strychnine from GlyR low affinity site in Wistar rat spinal cord by scintillation spectrometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycine receptor subunit alpha-1 (CHEMBL3246) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.32 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084712 | — | — | 1 | 6.90 |
| CHEMBL3084708 | — | — | 1 | 5.62 |
| CHEMBL3084717 | — | — | 1 | 5.37 |
| CHEMBL3084713 | — | — | 1 | 5.26 |
| CHEMBL3084705 | — | — | 1 | 5.10 |
| CHEMBL3084704 | — | — | 1 | 5.00 |
| CHEMBL3084715 | — | — | 1 | 4.68 |
| CHEMBL3084710 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084712 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3084708 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL3084717 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL3084713 | — | IC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL3084705 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3084704 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3084715 | — | IC50 | = | 20892.96 | nM | 4.68 |
| CHEMBL3084710 | — | IC50 | = | 22908.68 | nM | 4.64 |