Assay Detail
Functional
CHEMBL1065491
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Cytotoxicity against human HepG2 cells after 48 hrs by WST8 assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| IC50 | 4 | 5.93 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589366 | 3R14S-OCHRATOXIN A | — | 2 | 6.52 |
| CHEMBL592694 | 3S14S-OCHRATOXIN A | — | 2 | 6.40 |
| CHEMBL603156 | 3R14R-OCHRATOXIN A | — | 2 | 5.50 |
| CHEMBL600271 | 3S14R-OCHRATOXIN A | — | 2 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589366 | 3R14S-OCHRATOXIN A | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL592694 | 3S14S-OCHRATOXIN A | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL603156 | 3R14R-OCHRATOXIN A | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL600271 | 3S14R-OCHRATOXIN A | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | Activity | - | — | - | |
| CHEMBL592694 | 3S14S-OCHRATOXIN A | Activity | - | — | - | |
| CHEMBL603156 | 3R14R-OCHRATOXIN A | Activity | - | — | - | |
| CHEMBL600271 | 3S14R-OCHRATOXIN A | Activity | - | — | - |