Assay Detail
Functional
CHEMBL1065492
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Induction of apoptosis in human HepG2 cells assessed as caspase 3 activation after 24 hrs by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.58 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589366 | 3R14S-OCHRATOXIN A | — | 1 | 7.22 |
| CHEMBL592694 | 3S14S-OCHRATOXIN A | — | 1 | 7.10 |
| CHEMBL600271 | 3S14R-OCHRATOXIN A | — | 1 | 5.42 |
| CHEMBL603156 | 3R14R-OCHRATOXIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589366 | 3R14S-OCHRATOXIN A | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL592694 | 3S14S-OCHRATOXIN A | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL600271 | 3S14R-OCHRATOXIN A | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL603156 | 3R14R-OCHRATOXIN A | EC50 | > | 10000.0 | nM | - |